Caffeine Interactions
There are 109 drugs known to interact with caffeine, along with 9 disease interactions, and 5 alcohol/food interactions. Of the total drug interactions, 5 are major, 89 are moderate, and 15 are minor.
- View all 109 medications that may interact with caffeine
- View caffeine alcohol/food interactions (5)
- View caffeine disease interactions (9)
Most frequently checked interactions
View interaction reports for caffeine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Benadryl (diphenhydramine)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- CoQ10 (ubiquinone)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- Flonase (fluticasone nasal)
- Paracetamol (acetaminophen)
- Paracetamol (acetaminophen)
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Vyvanse (lisdexamfetamine)
- Xanax (alprazolam)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
- Zyrtec (cetirizine)
Caffeine alcohol/food interactions
There are 5 alcohol/food interactions with caffeine.
Caffeine disease interactions
There are 9 disease interactions with caffeine which include:
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
Report options
More about caffeine
- caffeine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (39)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Support group
- Drug class: CNS stimulants
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
