Aridol Side Effects

Generic name: mannitol

Medically reviewed by Drugs.com. Last updated on Jul 24, 2024.

Note: This document provides detailed information about Aridol Side Effects associated with mannitol. Some dosage forms listed on this page may not apply specifically to the brand name Aridol.

Applies to mannitol: intravenous solution.

Other dosage forms:

• inhalation capsule

Serious side effects of Aridol

Along with its needed effects, mannitol (the active ingredient contained in Aridol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking mannitol:

Incidence not known

• agitation
• bloating or swelling of the face, arms, hands, lower legs, or feet
• bloody or cloudy urine
• blue lips and fingernails
• blurred vision
• bulging soft spot on the head of an infant
• change in the ability to see colors, especially blue or yellow
• change in the amount or frequency of urine
• changes in skin color
• chest pain
• chills
• cloudy urine
• confusion
• cough
• coughing that sometimes produces a pink frothy sputum
• decreased awareness or responsiveness
• decreased urination
• depression
• difficult or labored breathing
• difficult, fast, or noisy breathing
• difficulty swallowing
• dilated neck veins
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• dry mouth
• extreme tiredness or weakness
• fainting
• fast, irregular, pounding, or racing heartbeat or pulse
• fever
• headache
• high blood pressure
• hives, itching, skin rash
• hostility
• increase in heart rate
• increased sweating
• increased thirst
• irregular breathing
• irritability
• lightheadedness
• loss of appetite
• loss of consciousness
• mood changes
• muscle pain, cramps, tremors, or twitching
• nausea
• nervousness
• not able to pass urine
• numbness or tingling in the hands, feet, or lips pain
• pain in lower back or side
• pain, redness, or pale skin at the injection site
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid weight gain
• rapid, deep breathing
• restlessness
• seizures
• severe sleepiness
• stomach cramps or pain
• sunken eyes
• tightness in the chest
• trouble sleeping
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• unusual weight gain or loss
• vomiting
• weakness or heaviness of the legs
• wrinkled skin

Other side effects of Aridol

Some side effects of mannitol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• bone or muscle stiffness
• difficulty in moving
• general feeling of discomfort or illness
• joint pain or swelling
• lack or loss of strength
• swelling or itching at the injection site

For healthcare professionals

Applies to mannitol: compounding powder, inhalation capsule, inhalation kit, intravenous solution, irrigation solution.

Cardiovascular

Cardiovascular side effects have included hypotension and tachycardia. Venous thrombosis or phlebitis extending from the injection site and hypervolemia have occurred rarely and are generally associated with the solution or technique used in administration.^[Ref]

Respiratory

Respiratory side effects have included pulmonary congestion and rhinitis. Respiratory side effects associated with mannitol (the active ingredient contained in Aridol) inhalation have included cough, gagging, wheeze, and decreased forced expiratory volume.^[Ref]

Metabolic

Metabolic side effects have included fluid and electrolyte imbalance, acidosis, and electrolyte loss.^[Ref]

Nervous system

Nervous system side effects have included headache, convulsions, and dizziness.^[Ref]

Hematologic

Hematologic side effects have included thrombophlebitis.^[Ref]

Other

Other side effects have included dryness of mouth, thirst, edema, arm pain, chills, dehydration, fever, mannitol (the active ingredient contained in Aridol) intoxication, and angina-like pain.^[Ref]

Eight cases of mannitol IV overdose in patients with preexisting renal failure were reviewed. Symptoms presented in the reviewed cases were CNS involvement out of proportion to uremia, severe hyponatremia, large osmolality gap, and fluid overload. Six patients were treated with hemodialysis, one patient with peritoneal dialysis, and one patient died before initiation of treatment. All patients received large doses over 1 to 3 days with a mean dose of 310 +/- 182.8 g. CNS involvement consisted of CNS depression, confusion, lethargy, stupor, and coma. Two patients recovered cerebral function and continued on lifetime dialysis, 3 patients recovered renal and cerebral function, and 1 patient recovered renal function but had severe cerebral dysfunction.^[Ref]

Renal

Renal side effects have included acute renal failure.^[Ref]

Local

Local side effects have included extravasation. This effect is generally attributed to the solution or technique used in administration.^[Ref]

Dermatologic

Dermatologic side effects have included urticaria and skin necrosis.^[Ref]

Ocular

Ocular side effects have included blurred vision.^[Ref]

Immunologic

Immunologic side effects have included infection at the injection site and febrile response. These effects are usually attributed to solution or technique used in administration.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting.^[Ref]

Genitourinary

Genitourinary side effects have included marked diuresis and urinary retention.^[Ref]

Psychiatric

Psychiatric side effects have rarely included mania (1 case report).^[Ref]

A 75-year-old woman with severe major depression experienced a manic episode 30 minutes after initiation of a 20% mannitol intravenous infusion for the treatment of acute angle closure glaucoma. The patient had been started on nortriptyline 50 mg per day for the treatment of depression ten days earlier. She received oral acetazolamide, topical pilocarpine, topical timolol, and topical dexamethasone concomitantly for the treatment of glaucoma. The mania resolved within approximately 1 hour following discontinuation of the mannitol infusion, and the patient returned to a severe depressive state. An extensive lab evaluation, toxicology screening, and medical examination failed to show additional secondary causes for mania in this patient.^[Ref]

Further information

Aridol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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