Skip to main content

Alphanine SD Side Effects

Generic name: coagulation factor ix

Medically reviewed by Last updated on May 31, 2024.

Note: This document contains side effect information about coagulation factor ix. Some dosage forms listed on this page may not apply to the brand name Alphanine SD.

Applies to coagulation factor ix: intravenous powder for solution.

Serious side effects of Alphanine SD

Along with its needed effects, coagulation factor ix (the active ingredient contained in Alphanine SD) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking coagulation factor ix:

More common

Less common

Incidence not known

Other side effects of Alphanine SD

Some side effects of coagulation factor ix may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to coagulation factor ix: intravenous kit, intravenous powder for injection.


Frequency not reported: Hypersensitivity (including bronchospastic reactions and/or hypotension, anaphylaxis, development of high-titer inhibitors necessitating alternative treatment)[Ref]


Common (1% to 10%): Factor IX inhibition[Ref]


Common (1% to 10%): Nausea, vomiting[Ref]


Common (1% to 10%): Rash pruritic, hives[Ref]


Common (1% to 10%): Injection site discomfort, injection site pain[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia, lethargy, dizziness, shaking, drowsiness[Ref]


Common (1% to 10%): Dry cough, hypoxia, chest tightness, dyspnea[Ref]


Common (1% to 10%): Renal infarct[Ref]

The renal infarct occurred in a hepatitis C antibody positive patients 12 days after treatment of a bleeding episode; the relation of the infarct to the prior administration of this drug is uncertain.[Ref]


Common (1% to 10%): Blurred vision[Ref]


Common (1% to 10%): Influenza, cellulitis at injection site, phlebitis at injection site[Ref]


Common (1% to 10%): Apathy, depression[Ref]


Common (1% to 10%): Hemophilia (lack of efficacy), asthenia, fever, chills[Ref]


Common (1% to 10%): Flushing[Ref]


1. (2022) "Product Information. Benefix (coagulation factor IX)." Wyeth Laboratories

2. (2022) "Product Information. Ixinity (coagulation factor IX)." Cangene bioPharma, Inc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.