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Acetylcholine ophthalmic Side Effects

Medically reviewed by Last updated on Jun 3, 2022.

Applies to acetylcholine ophthalmic: intraocular solution reconstituted.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Change in eyesight, eye pain, or very bad eye irritation.

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child's doctor or get medical help if your child has any side effects that bother your child or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to acetylcholine ophthalmic: compounding powder, intraocular powder for reconstitution.


The most commonly reported side effects were corneal edema, corneal clouding, and corneal decompensation.[Ref]


Rare (less than 0.1%): Bradycardia, hypotension, flushing[Ref]


Uncommon (0.1% to 1%): Corneal edema, corneal clouding, corneal decompensation[Ref]


Rare (less than 0.1%): Breathing difficulties[Ref]


Rare (less than 0.1%): Sweating[Ref]


1. "Product Information. Miochol (acetylcholine ophthalmic)." Ciba Vision Ophthalmics

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.