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Klor-Con Powder

Generic name: potassium chloride
Dosage form: powder, for oral solution
Drug class: Minerals and electrolytes

Medically reviewed by Last updated on Sep 1, 2020.

Indications and Usage for Klor-Con Powder

Klor-Con® powder (potassium chloride) is indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods or diuretic dose reduction is insufficient.

Klor-Con Powder Dosage and Administration

Administration and Monitoring

If serum potassium concentration is <2.5 mEq/L, use intravenous potassium instead of oral supplementation.


Monitor serum potassium and adjust dosages accordingly. For treatment of hypokalemia, monitor potassium levels daily or more often depending on the severity of hypokalemia until they return to normal. Monitor potassium levels monthly to biannually for maintenance or prophylaxis.

The treatment of potassium depletion, particularly in the presence of cardiac disease, renal disease, or acidosis requires careful attention to acid-base balance, volume status, electrolytes, including magnesium, sodium, chloride, phosphate, and calcium, electrocardiograms and the clinical status of the patient. Correct volume status, acid-base balance and electrolyte deficits as appropriate.


Dilute the contents of 1 packet of potassium chloride for oral solution with 4 ounces of cold water or other beverage [see Warnings and Precautions (5.1)].

Take with meals or immediately after eating.

Adult Dosing

Treatment of hypokalemia:

Daily dose range from 40 to 100 mEq. Give in 2 to 5 divided doses: limit doses to 40 mEq per dose. The total daily dose should not exceed 200 mEq in a 24 hour period.

Maintenance or Prophylaxis:

Typical dose is 20 mEq per day. Individualize dose based upon serum potassium levels.

Studies support the use of potassium replacement in digitalis toxicity. When alkalosis is present, normokalemia and hyperkalemia may obscure a total potassium deficit. The advisability of use of potassium replacement in the setting of hyperkalemia is uncertain.

Pediatric Dosing

Treatment of hypokalemia:

Pediatric patients aged birth to 16 years old: The initial dose is 2 to 4 mEq/kg/day in divided doses; do not exceed as a single dose 1 mEq/kg or 40 mEq, whichever is lower; maximum daily doses should not exceed 100 mEq. If deficits are severe or ongoing losses are great, consider intravenous therapy.

Maintenance or Prophylaxis

Pediatric patients aged birth to 16 years old: Typical dose is 1 mEq/kg/day. Do not exceed 3 mEq/kg/day.

Dosage Forms and Strengths

Each packet contains 1.5 g of potassium chloride supplying 20 mEq of potassium and 20 mEq of chloride.


Klor-Con Powder is contraindicated in patients on potassium sparing diuretics.

Warnings and Precautions

Gastrointestinal Irritation

May cause gastrointestinal irritation. Increased dilution of the solution and taking with meals may reduce gastrointestinal irritation [see Dosage and Administration (2.1)].

Adverse Reactions

The most common adverse reactions to oral potassium salts are nausea, vomiting, flatulence, abdominal pain/discomfort, and diarrhea.

Drug Interactions

Potassium-Sparing Diuretics

Use with potassium-sparing diuretics can produce severe hyperkalemia. Avoid concomitant use.

Renin-Angiotensin-Aldosterone System Inhibitors

Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production. Closely monitor potassium in patients receiving concomitant RAAS therapy.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

NSAIDs may produce potassium retention by reducing renal synthesis of prostaglandin E and impairing the renin-angiotensin system. Closely monitor potassium in patients on concomitant NSAIDs.



There are no human data related to use of Potassium Chloride during pregnancy, and animal studies have not been conducted. Potassium supplementation that does not lead to hyperkalemia is not expected to cause fetal harm.

The background risk for major birth defects and miscarriage in the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.


Risk Summary

The normal potassium ion content of human milk is about 13 mEq per liter. Since potassium from oral supplements such as Potassium Chloride becomes part of the body potassium pool, as long as body potassium is not excessive, the contribution of potassium chloride supplementation should have little or no effect on the level in human milk.

Pediatric Use

Clinical trial data from published literature have demonstrated the safety and effectiveness of potassium chloride in children with diarrhea and malnutrition from birth to 16 years.

Geriatric Use

Clinical studies of potassium chloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.


Patients with cirrhosis should usually be started at the low end of the dosing range, and the serum potassium level should be monitored frequently [see Clinical Pharmacology (12.3)].

Renal Impairment

Patients with renal impairment have reduced urinary excretion of potassium and are at substantially increased risk of hyperkalemia. Patients with impaired renal function, particularly if the patient is on ACE inhibitors, ARBs, or nonsteroidal anti-inflammatory drugs should usually be started at the low end of the dosing range because of the potential for development of hyperkalemia. The serum potassium level should be monitored frequently. Renal function should be assessed periodically.



The administration of oral potassium salts to persons with normal excretory mechanisms for potassium rarely causes serious hyperkalemia. However, if excretory mechanisms are impaired or if potassium is administered too rapidly potentially fatal hyperkalemia can result.

Hyperkalemia is usually asymptomatic and may be manifested only by an increased serum potassium concentration (6.5 to 8.0 mEq/L) and characteristic electrocardiographic changes (peaking of T-waves, loss of P-waves, depression of S-T segment, and prolongation of the QT-interval). Late manifestations include muscle paralysis and cardiovascular collapse from cardiac arrest (9 to 12 mEq/L).


Treatment measures for hyperkalemia include the following:

  1. Monitor closely for arrhythmias and electrolyte changes.
  2. Eliminate foods and medications containing potassium and of any agents with potassium-sparing properties such as potassium-sparing diuretics, ARBs, ACE inhibitors, NSAIDs, certain nutritional supplements and many others.
  3. Administer intravenous calcium gluconate if the patient is at no risk or low risk of developing digitalis toxicity.
  4. Administer intravenously 300 to 500 mL/hr of 10% dextrose solution containing 10 to 20 units of crystalline insulin per 1000 mL.
  5. Correct acidosis, if present, with intravenous sodium bicarbonate.
  6. Use exchange resins, hemodialysis, or peritoneal dialysis.

In patients who have been stabilized on digitalis, too rapid a lowering of the serum potassium concentration can produce digitalis toxicity.

Klor-Con Powder Description

Potassium chloride is a white crystalline or colorless solid. It is soluble in water and slightly soluble in alcohol. Chemically, potassium chloride is KCl with a molecular mass of 74.55.

Each packet of light orange powder contains 1.5 g of potassium chloride, USP, which is equivalent to potassium 20 mEq and chloride 20 mEq. Each packet of Klor-Con Powder contains the following inactive ingredients: FD&C Yellow No. 6, malic acid, neotame, and natural orange flavor (Modified food starch (with added corn syrup), maltodextrin, citric acid, silicon dioxide and natural tocopherols).

Klor-Con Powder - Clinical Pharmacology

Mechanism of Action

The potassium ion (K+) is the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity; the transmission of nerve impulses; the contraction of cardiac, skeletal, and smooth muscle; and the maintenance of normal renal function.

The intracellular concentration of potassium is approximately 150 to 160 mEq per liter. The normal adult plasma concentration is 3.5 to 5 mEq per liter. An active ion transport system maintains this gradient across the plasma membrane.

Potassium is a normal dietary constituent, and under steady-state conditions the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine. The usual dietary intake of potassium is 50 to 100 mEq per day.


Based on published literature, the rate of absorption and urinary excretion of potassium from KCl oral solution were higher during the first few hours after dosing relative to modified release KCl products. The bioavailability of potassium, as measured by the cumulative urinary excretion of K+ over a 24 hour post dose period, is similar for KCl solution and modified release products.

Specific Populations


Based on published literature, the baseline corrected serum concentrations of potassium measured over 3 h after administration in cirrhotic subjects who received an oral potassium load rose to approximately twice that of normal subjects who received the same load.

How Supplied/Storage and Handling

Klor-Con® powder (potassium chloride for oral solution, USP) is a light orange powder available in one strength as follows:

20 mEq

Each packet contains 1.5 g of potassium chloride providing potassium 20 mEq and chloride 20 mEq supplied in:

Cartons of 30 packets NDC 0245-0360-30
Cartons of 100 packets NDC 0245-0360-01


Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in tight, light-resistant container as defined in the USP.


Manufactured by
Maple Grove, MN 55369

Klor-Con is a registered trademark of Upsher-Smith Laboratories, LLC.

Revised 0320


NDC 0245-0360-30
(Potassium Chloride
for Oral Solution, USP)

20 mEq

Orange Flavored

Each packet contains: Potassium Chloride 1.5 g

30 Single-Dose Packets
Rx only


potassium chloride powder, for solution
Product Information
Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:0245-0360
Route of Administration ORAL DEA Schedule
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
potassium chloride (potassium cation) potassium chloride 1.5 g
Inactive Ingredients
Ingredient Name Strength
malic acid
silicon dioxide
FD&C yellow no. 6
modified corn starch (1-octenyl succinic anhydride)
citric acid monohydrate
Product Characteristics
Color ORANGE (light) Score
Shape Size
Flavor ORANGE Imprint Code
# Item Code Package Description
1 NDC:0245-0360-30 30 PACKET in 1 CARTON
1 NDC:0245-0360-89 1 POWDER, FOR SOLUTION in 1 PACKET
2 NDC:0245-0360-01 100 PACKET in 1 CARTON
2 NDC:0245-0360-89 1 POWDER, FOR SOLUTION in 1 PACKET
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
ANDA ANDA209662 10/23/2017
Labeler - Upsher-Smith Laboratories, LLC (079111820)
Name Address ID/FEI Operations
Upsher-Smith Laboratories, LLC 079111820 MANUFACTURE(0245-0360), LABEL(0245-0360), PACK(0245-0360)
Name Address ID/FEI Operations
Upsher-Smith Laboratories, LLC 047251004 ANALYSIS(0245-0360)
Upsher-Smith Laboratories, LLC