Medically reviewed by Drugs.com. Last updated on Aug 7, 2020.
(SOW dee um EYE oh dide)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Iodopen: 100 mcg/mL (10 mL [DSC])
Brand Names: U.S.
- Iodopen [DSC]
- Trace Element, Parenteral
Iodine is required for thyroid hormone synthesis.
Urine (major); bile (minor)
Use: Labeled Indications
Iodine supplement: Supplement to intravenous solutions given for total parenteral nutrition (TPN) to prevent depletion of endogenous iodine stores and subsequent deficiency symptoms.
Known hypersensitivity to iodine or any component of the formulation; undiluted administration into a peripheral vein
Iodine supplement: IV: 1 to 2 mcg/kg/day (usual range: 75 to 150 mcg/day) administered in TPN solution. For women who are pregnant or breast-feeding, 2 to 3 mcg/kg/day administered in TPN solution
Refer to adult dosing.
Iodine supplement: Children and Adolescents: IV: 2 to 3 mcg/kg/day administered in TPN solution
IV: Administer in admixtures only. Do not administer undiluted into a peripheral vein; phlebitis may occur.
Dietary reference intake for iodine (IOM 2001):
0 to 6 months: Adequate intake: 110 mcg/day
7 to 12 months: Adequate intake: 130 mcg/day
1 to 8 years: RDA: 90 mcg/day
9 to 13 years: RDA: 120 mcg/day
≥14 years: RDA: 150 mcg/day
Pregnancy: RDA: 220 mcg/day
Lactation: RDA: 290 mcg/day
Store at 20°C to 25°C (68°F to 77°F).
Sodium Iodide I131: Sodium Iodide may diminish the therapeutic effect of Sodium Iodide I131. Management: Discontinue sodium iodide supplementation at least 10 days before sodium iodide I-131 administration, and avoid concurrent use. Avoid combination
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined.
Hematologic & oncologic: Eosinophilia, hemorrhage, lymph node hyperplasia
Hypersensitivity: Anaphylactic shock, angioedema, hypersensitivity
Neuromuscular & skeletal: Arthralgia
Concerns related to adverse effects:
• Hypersensitivity reactions: Hypersensitivity reactions, including anaphylactic shock (sometimes fatal), have been reported; evaluate patients for iodide sensitivity prior to administration and discontinue immediately if a reaction occurs.
• Renal impairment: Use with caution; iodine supplements in total parenteral nutrition solutions may need to be adjusted, reduced, or omitted.
Dosage form specific issues:
• Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register 2002). See manufacturer's labeling.
• Appropriate use: Sodium iodide is a hypotonic solution; administer in admixtures only.
• Other sources of iodine: Iodine is readily absorbed through skin, lungs, and mucous membranes; consider environmental and topical (eg, topical skin disinfectants, surgical swabs, solutions) sources of iodine and their contribution to iodine stores.
Periodically monitor thyroid function
Sodium iodide for injection may be used in pregnant women as an iodine supplement when needed in total parenteral nutrition (TPN). An adequate amount of iodine intake is essential for thyroid function. Iodine crosses the placenta and requirements are increased during pregnancy. Iodine deficiency in pregnancy can lead to neurologic damage in the newborn; an extreme form, cretinism, is characterized by gross mental retardation, short stature, deaf mutism, and spasticity. Large amounts of iodine during pregnancy can cause fetal goiter or hyperthyroidism (IOM 2001).
What is this drug used for?
• It is used to give electrolytes to the body when more are needed. This product must be mixed in TPN solution before it is given.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
• Joint pain
• Swollen glands
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
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