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Sodium Iodide

Medically reviewed by Drugs.com. Last updated on Aug 7, 2020.

Pronunciation

(SOW dee um EYE oh dide)

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Injection:

Iodopen: 100 mcg/mL (10 mL [DSC])

Brand Names: U.S.

  • Iodopen [DSC]

Pharmacologic Category

  • Trace Element, Parenteral

Pharmacology

Iodine is required for thyroid hormone synthesis.

Absorption

Rapid (oral)

Excretion

Urine (major); bile (minor)

Use: Labeled Indications

Iodine supplement: Supplement to intravenous solutions given for total parenteral nutrition (TPN) to prevent depletion of endogenous iodine stores and subsequent deficiency symptoms.

Contraindications

Known hypersensitivity to iodine or any component of the formulation; undiluted administration into a peripheral vein

Dosing: Adult

Iodine supplement: IV: 1 to 2 mcg/kg/day (usual range: 75 to 150 mcg/day) administered in TPN solution. For women who are pregnant or breast-feeding, 2 to 3 mcg/kg/day administered in TPN solution

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Iodine supplement: Children and Adolescents: IV: 2 to 3 mcg/kg/day administered in TPN solution

Administration

IV: Administer in admixtures only. Do not administer undiluted into a peripheral vein; phlebitis may occur.

Dietary Considerations

Dietary reference intake for iodine (IOM 2001):

0 to 6 months: Adequate intake: 110 mcg/day

7 to 12 months: Adequate intake: 130 mcg/day

1 to 8 years: RDA: 90 mcg/day

9 to 13 years: RDA: 120 mcg/day

≥14 years: RDA: 150 mcg/day

Pregnancy: RDA: 220 mcg/day

Lactation: RDA: 290 mcg/day

Storage

Store at 20°C to 25°C (68°F to 77°F).

Drug Interactions

Sodium Iodide I131: Sodium Iodide may diminish the therapeutic effect of Sodium Iodide I131. Management: Discontinue sodium iodide supplementation at least 10 days before sodium iodide I-131 administration, and avoid concurrent use. Avoid combination

Adverse Reactions

Frequency not defined.

Hematologic & oncologic: Eosinophilia, hemorrhage, lymph node hyperplasia

Hypersensitivity: Anaphylactic shock, angioedema, hypersensitivity

Neuromuscular & skeletal: Arthralgia

Miscellaneous: Fever

Warnings/Precautions

Concerns related to adverse effects:

• Hypersensitivity reactions: Hypersensitivity reactions, including anaphylactic shock (sometimes fatal), have been reported; evaluate patients for iodide sensitivity prior to administration and discontinue immediately if a reaction occurs.

Disease-related concerns:

• Renal impairment: Use with caution; iodine supplements in total parenteral nutrition solutions may need to be adjusted, reduced, or omitted.

Dosage form specific issues:

• Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register 2002). See manufacturer's labeling.

Other warnings/precautions:

• Appropriate use: Sodium iodide is a hypotonic solution; administer in admixtures only.

• Other sources of iodine: Iodine is readily absorbed through skin, lungs, and mucous membranes; consider environmental and topical (eg, topical skin disinfectants, surgical swabs, solutions) sources of iodine and their contribution to iodine stores.

Monitoring Parameters

Periodically monitor thyroid function

Pregnancy Considerations

Sodium iodide for injection may be used in pregnant women as an iodine supplement when needed in total parenteral nutrition (TPN). An adequate amount of iodine intake is essential for thyroid function. Iodine crosses the placenta and requirements are increased during pregnancy. Iodine deficiency in pregnancy can lead to neurologic damage in the newborn; an extreme form, cretinism, is characterized by gross mental retardation, short stature, deaf mutism, and spasticity. Large amounts of iodine during pregnancy can cause fetal goiter or hyperthyroidism (IOM 2001).

Patient Education

What is this drug used for?

• It is used to give electrolytes to the body when more are needed. This product must be mixed in TPN solution before it is given.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Bruising

• Bleeding

• Chills

• Joint pain

• Swollen glands

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine’s uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

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