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Potassium P-Aminobenzoate

Medically reviewed by Last updated on Aug 7, 2020.


(poe TASS ee um pe a mee noe BEN zoe ate)

Index Terms

  • Aminobenzoate Potassium
  • Potassium Aminobenzoate

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Potaba: 500 mg

Packet, Oral:

Generic: 2 g (50 ea)

Brand Names: U.S.

  • Potaba

Pharmacologic Category

  • Vitamin, Water Soluble


P-aminobenzoate is a member of the vitamin B complex family. It may have an antifibrotic effect due to increased oxygen uptake at the tissue level.

Use: Labeled Indications

Presently, all indications are classified by the FDA as “possibly effective.”

Treatment of scleroderma, dermatomyositis, morphea, linear scleroderma, pemphigus, Peyronie's disease


Hypersensitivity to potassium p-aminobenzoate or any component of the formulation; concurrent use of sulfonamides

Dosing: Adult

Oral: Average dose: 12 g/day in 4-6 divided doses

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Oral: 1 g/10 pounds of weight/day; administer in divided doses


All forms should be administered after meals or with a snack.

Capsule: Take with a glass of water.

Dietary Considerations

Take with food to avoid stomach upset.

Drug Interactions

Sulfonamide Antibiotics: Potassium P-Aminobenzoate may diminish the therapeutic effect of Sulfonamide Antibiotics. Avoid combination

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined.

Dermatologic: Skin rash

Gastrointestinal: Anorexia, nausea

Hypersensitivity: Hypersensitivity reaction

Miscellaneous: Fever


Concerns related to adverse effects:

• Anorexia: Interrupt therapy if anorexia occurs; may reinstitute once patient improves.

• Nausea: Interrupt therapy if nausea occurs; may reinstitute once patient improves.

Disease-related concerns:

• Diabetes: Use with caution in patients with diabetes mellitus or a history of hypoglycemia.

• Renal impairment: Use with caution in patients with renal impairment.

Pregnancy Considerations

Safety for use in pregnancy has not been established.

Patient Education

What is this drug used for?

• It is used to treat autoimmune diseases.

• It is used to treat Peyronie's disease.

• It may be given to you for other reasons. Talk with the doctor.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Lack of appetite

• Nausea

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.