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Medically reviewed by Last updated on Jul 29, 2019.


(oz en OX a sin)

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Cream, External:

Xepi: 1% (30 g) [contains benzoic acid, propylene glycol]

Brand Names: U.S.

  • Xepi

Pharmacologic Category

  • Antibiotic, Quinolone
  • Antibiotic, Topical


Ozenoxacin is a quinolone antimicrobial that inhibits the bacterial DNA replication enzymes, DNA gyrase A, and topoisomerase IV.



Use: Labeled Indications

Impetigo: Treatment of impetigo due to Staphylococcus aureus or Streptococcus pyogenes in adult and pediatric patients ≥2 months of age


There are no contraindications listed in the manufacturer's labeling.

Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to ozenoxacin or any component of the formulation

Dosing: Adult

Impetigo: Topical: Apply a thin layer to affected area (up to 100 cm2) twice daily for 5 days.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Impetigo: Infants ≥2 months of age, Children, and Adolescents: Topical: Apply a thin layer to the affected area twice daily for 5 days. Note: Affected area may be up to 2% of the total BSA (not exceeding 100 cm2) for patients <12 years or up to 100 cm2 for patients ≥12 years.


Topical: For topical use only; not for oral, ophthalmic, intranasal, or intravaginal use. Apply a thin layer to affected area; wash hands after application. Treated area may be covered with a sterile bandage or gauze dressing.


Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

<1%, postmarketing, and/or case reports: Rosacea-like face eruption, seborrheic dermatitis


Concerns related to adverse effects:

• Superinfection: Prolonged use may result in fungal or bacterial superinfection; discontinue use if superinfection occurs.

Other warnings/precautions:

• Appropriate use: For topical use only; not for oral, ophthalmic, intranasal, or intravaginal use.

Pregnancy Considerations

Systemic absorption following topical application is negligible; exposure to the fetus is not expected.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Have patient report immediately to prescriber severe skin irritation (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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