Skip to Content

Benzocaine and Docusate

Medically reviewed by Drugs.com. Last updated on May 20, 2020.

Pronunciation

(BEN zoe kane & DOK ue sate)

Index Terms

  • Docusate and Benzocaine
  • Docusate Sodium and Benzocaine
  • Docusol Plus
  • Enemeez Plus

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Enema, Rectal:

DocuSol Plus Mini-Enema: Benzocaine 20 mg and docusate sodium 283 mg (5 ea)

Brand Names: U.S.

  • DocuSol Plus Mini-Enema [OTC]

Pharmacologic Category

  • Analgesic, Topical
  • Local Anesthetic
  • Stool Softener

Pharmacology

Docusate is a stool softener; benzocaine is a local anesthetic.

Onset of Action

Rectal: 2 to 15 minutes.

Use: Labeled Indications

Constipation: Relief of occasional constipation (irregularity) in patients ≥12 years of age who experience painful bowel movements.

Contraindications

OTC labeling: When used for self-medication, do not use for longer than 7 days; when abdominal pain, nausea, or vomiting is present; or concomitantly with mineral oil (oral products only); hypersensitivity to benzocaine or any component of the formulation.

Dosing: Adult

Constipation: Rectal: Benzocaine 20 mg/docusate sodium 283 mg per 5 mL: 5 mL (1 unit) 1 to 3 times daily.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Constipation: Children ≥12 years and Adolescents: Rectal: Enema (benzocaine 20 mg/docusate sodium 283 mg per 5 mL unit): 5 mL (1 unit) 1 to 3 times daily; produces a bowel movement within 2 to 15 minutes; may use up to 7 days or as directed by a physician. Note: If transitioning off bisacodyl product, allow 3 days before initiating benzocaine/docusate therapy; typically not used concomitantly with mineral oil.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Administration

Rectal: For rectal use only. Lubricate tip prior to insertion by placing a few drops of the liquid from the enema on the shaft prior to insertion; may also apply a few drops of enema contents or lubricant to the anus prior to insertion. Gently insert lubricated applicator tip into rectum. Grasp bottle firmly and squeeze slowly to empty the contents. Discard after administration.

Storage

Store at 15°C to 30°C (59°F to 86°F).

Drug Interactions

Dapsone (Topical): May enhance the adverse/toxic effect of Methemoglobinemia Associated Agents. Monitor therapy

Local Anesthetics: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Monitor therapy

Methemoglobinemia Associated Agents: May enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Monitor therapy

Nitric Oxide: May enhance the adverse/toxic effect of Methemoglobinemia Associated Agents. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Monitor therapy

Prilocaine: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Prilocaine. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Management: Monitor patients for signs of methemoglobinemia (e.g., hypoxia, cyanosis) when prilocaine is used in combination with other agents associated with development of methemoglobinemia. Avoid lidocaine/prilocaine in infants receiving such agents. Monitor therapy

Sodium Nitrite: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Sodium Nitrite. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Monitor therapy

Adverse Reactions

There are no adverse reactions listed in the manufacturer's labeling. Also see Docusate monograph.

Warnings/Precautions

Dosage forms specific issues:

• Enema: For rectal use only; lubricate tip prior to insertion. Discontinue use and notify health care provider if rash around the anus/rectal irritation occurs or if resistance is encountered with insertion; forcing the tube may result in injury or damage to the rectum.

Other warnings/precautions:

• Self-medication (OTC use): When used for self-medication (OTC), patients should be instructed to discontinue use and notify a health care provider if rectal bleeding occurs, if a sudden change in bowel habits occurs and persists over 14 days, or if a bowel movement fails to occur after use.

Monitoring Parameters

Periodic rectal exams are recommended in patients with impaired rectal function, especially loss of sensation.

Pregnancy Considerations

Refer to individual monographs.

Patient Education

What is this drug used for?

• It is used to treat constipation.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Rectal irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about benzocaine / docusate topical

Consumer resources

Related treatment guides