Semaglutide May Lower Risk for Opioid Overdose in T2DM, Opioid Use Disorder
WEDNESDAY, Sept. 25, 2024 -- For patients with type 2 diabetes (T2D) and opioid use disorder (OUD), semaglutide is associated with a significantly lower risk for opioid overdose compared with other antidiabetic medications, according to a research letter published online Sept. 25 in JAMA Network Open.
William Wang, from the Case Western Reserve University School of Medicine in Cleveland, and colleagues conducted an emulation target trial to compare the association of semaglutide versus other antidiabetic medications with opioid overdose risk among patients with comorbid T2D and OUD. The study included 33,006 eligible patients: 3,034 prescribed semaglutide and 29,972 prescribed other antidiabetic medications.
The researchers found that during one-year follow-up, semaglutide was associated with a significantly lower risk for opioid overdose compared with other antidiabetic medications, including other glucagon-like peptide 1 receptor agonists, with hazard ratios varying from 0.32 to 0.58. No difference between the groups was seen in the negative control outcome (medical encounters for congenital malformations, deformations, and chromosomal abnormalities).
"Semaglutide was associated with reduced opioid overdose risk in patients with comorbid T2D and OUD, suggesting its potential therapeutic value for preventing overdoses," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Hepatitis B Virus Immunity Linked to Reduced Risk for Diabetes
THURSDAY, Sept. 11, 2025 -- Hepatitis B virus (HBV) immunity in individuals without HBV infection is associated with a reduced risk for diabetes, according to a study published...
Sugar Consumption Positively Related to Temperature
WEDNESDAY, Sept. 10, 2025 -- Sugar consumption is positively related to temperature, mainly driven by increased intake of sugar-sweetened beverages and frozen desserts, according...
Poor Cardiovascular-Kidney-Metabolic Health Increases Psoriasis Risk
WEDNESDAY, Sept. 10, 2025 -- Poor cardiovascular-kidney-metabolic (CKM) health is associated with an increased risk for psoriasis, especially for those with high genetic risk...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.