Skip to main content

Probiotics Linked to Reduced Mortality in Infants Born Before 34 Weeks

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 12, 2025.

via HealthDay

WEDNESDAY, Feb. 12, 2025 -- For infants born before 34 weeks of gestation and with a birth weight <1,000 g, probiotics used in neonatal units are associated with reduced mortality, according to a study published online Feb. 12 in Pediatrics.

Belal N. Alshaikh, M.D., M.P.H., from the University of Calgary Cumming School of Medicine in Alberta, Canada, and colleagues conducted a retrospective cohort study involving infants born before 34 weeks of gestation and admitted to 33 Canadian Neonatal Network units from Jan. 1, 2016, to Dec. 31, 2022. The effectiveness and risks for probiotics were examined among infants born before 34 weeks of gestation and with a birth weight <1,000 g.

The researchers found that 57.5 and 42.5 percent of the 32,667 eligible infants received probiotics and did not receive probiotics, respectively. Probiotics were associated with reduced mortality rates (adjusted odds ratio [aOR], 0.62; 98.3 percent confidence interval [CI], 0.53 to 0.73), but not with reduced rates of necrotizing enterocolitis (aOR, 0.92; 98.3 percent CI, 0.78 to 1.09) or late-onset sepsis (aOR, 0.90; 98.3 percent CI, 0.80 to 1.01). Probiotics were associated with reduced mortality rates in the 7,401 infants with a birth weight <1,000 g (aOR, 0.58; 98.3 percent CI, 0.47 to 0.71), but not with decreased rates of necrotizing enterocolitis (aOR, 0.90; 98.3 percent CI, 0.71 to 1.13) or late-onset sepsis (aOR, 1.01; 98.3 percent CI, 0.86 to 1.18). In 27 and 20 infants born before 34 weeks of gestation and with a birth weight <1,000 g, probiotic sepsis occurred (1.4 and 4.0 per 1,000, respectively). Three infants with probiotic sepsis died; in two cases, probiotic sepsis was deemed a possible cause.

"Our findings can help health care providers counsel parents on the benefits and risks of probiotics," the authors write.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Higher Mental Well-Being Tied to Lower Fear of Childbirth

WEDNESDAY, Aug. 13, 2025 -- A woman’s sense of mental well-being is the strongest predictor of how fearful she is about childbirth, according to a study published online...

Reciprocal Relationships Identified Between Gut Bacteria and Insomnia

WEDNESDAY, Aug. 13, 2025 -- There appear to be reciprocal links between certain gut bacteria and insomnia risk, according to a study published online Aug. 12 in General...

Prevalence of Disorders of Gut-Brain Interaction Increased After Pandemic

TUESDAY, Aug. 5, 2025 -- The prevalence of disorders of the gut-brain interaction (DGBI) increased from before to after the COVID-19 pandemic, according to a study published...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.