Preconception Hypoglycemia Linked to Adverse Pregnancy Outcomes
By Elana Gotkine HealthDay Reporter
MONDAY, Aug. 4, 2025 -- Preconception hypoglycemia is associated with adverse pregnancy outcomes, according to a study published online July 29 in PLOS Medicine.
Hanbin Wu, from the Prince of Wales Hospital at The Chinese University of Hong Kong, and colleagues examined the association between maternal preconception hypoglycemia and adverse pregnancy outcomes among childbearing-aged women in China in a retrospective cohort study. Data were included for women aged 20 to 49 years who successfully conceived within one year without multiple gestations and had complete information on pregnancy outcomes from the National Free Preconception Checkup Project (4,866,919 women).
Overall, 239,128 women (4.91 percent) had preconception hypoglycemia. The researchers found that women with preconception hypoglycemia had increased inverse probability treatment weighting adjusted odds ratios of preterm birth, low birth weight, small for gestational age, and birth defects by 10, 8, 7, and 21 percent, respectively, compared with the group without preconception hypoglycemia, while the odds ratios of medical abortion, miscarriage or early stillbirth, macrosomia, and large for gestational age decreased by 6, 5, 12, and 12 percent, respectively. Among body mass index groups, the associations of maternal preconception hypoglycemia and adverse pregnancy outcomes varied. For example, women with underweight had a lower risk for medical abortion, miscarriage or early stillbirth, and large for gestational age in association with preconception hypoglycemia.
"Our findings indicated that further attention should be paid to women with hypoglycemia prior to pregnancy, and screening for preconception hypoglycemia might be worth exploring as a means to reduce adverse pregnancy outcomes," the authors write.
Several authors disclosed ties to the biopharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2025
Read this next
Higher Mental Well-Being Tied to Lower Fear of Childbirth
WEDNESDAY, Aug. 13, 2025 -- A woman’s sense of mental well-being is the strongest predictor of how fearful she is about childbirth, according to a study published online...
Study Estimates Global Burden of Vertically Transmitted Hepatitis C
TUESDAY, Aug. 5, 2025 -- Each year, nearly 74,000 children are born with hepatitis C virus (HCV) around the world, according to a study published online July 23 in The Lancet...
Mental Illness Increased During, After Pregnancy for Gestational Carriers
MONDAY, Aug. 4, 2025 -- Gestational carriers seem to be more likely to be diagnosed with mental illness during and after pregnancy than those with unassisted pregnancies or...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.