Offspring of Women With Epilepsy Experience Decreased Bone Metabolism
By Lori Solomon HealthDay Reporter
FRIDAY, Feb. 14, 2025 -- Women with epilepsy may have offspring with decreased bone metabolism and lower birth weight, according to a study published online Feb. 3 in the Annals of Clinical and Translational Neurology.
Huali Luo, from Zhejiang University in China, and colleagues retrospectively analyzed data from 83 parturients with epilepsy receiving antenatal care (2012 through 2021) and a control group of 249 parturients without epilepsy.
The researchers found that women with epilepsy were significantly more likely to undergo a cesarean section with a lower abortion rate (55.4 versus 37.3 percent). Offspring femoral length in women with epilepsy was significantly reduced versus the control group (6.812 versus 6.923 cm) when adjusting for potential confounding variables. Compared with offspring whose mothers used a single antiseizure medication (ASM) or none, those born to mothers using multiple ASMs had significantly reduced femoral and biparietal lengths. Additionally, using multiple ASMs was associated with significantly lower birth weight in offspring versus women not using ASMs.
"The application of a single ASM during pregnancy is the optimal choice for pregnant women with epilepsy and their offspring, as it can not only control the seizures to reduce the harm caused by seizures during pregnancy but also minimize the restriction of ASMs on the growth and development of offspring," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted February 2025
Read this next
Specific Antiseizure Medications Associated With Major Malformations in Infants
FRIDAY, July 18, 2025 -- Maternal use of valproate, phenobarbital, and topiramate early in pregnancy is associated with an increased risk for major malformations in infants...
ENDO: Osteoporosis Treatment Benefits Elderly Patients With Fragility Fracture
THURSDAY, July 17, 2025 -- Patients with osteoporosis who suffer a fragility fracture at age 80 years or older have better five-year outcomes if they receive treatment for...
AI Can Accurately Estimate Bone Mineral Density and Classify Osteoporosis
WEDNESDAY, July 16, 2025 -- An artificial intelligence (AI)-assisted diagnostic system can accurately estimate bone mineral density (BMD) and classify osteoporosis category...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.