Many Ineligible for Clinical Trial Could Benefit From Teclistamab for Multiple Myeloma
WEDNESDAY, July 16, 2025 -- In a study published online July 9 in Blood Cancer Discovery, real-world outcomes are described for teclistamab, a T-cell-engaging bispecific antibody that targets multiple myeloma (MM) cells via the B-cell maturation antigen (BCMA) receptor.
Beatrice M. Razzo, M.D., from the University of Pennsylvania in Philadelphia, and colleagues conducted a retrospective cohort study of postapproval, real-world outcomes with teclistamab in the U.S. MM Immunotherapy Consortium.
The researchers found that 89 percent of the 509 patients would have been ineligible for the MajesTEC-1 trial, mainly due to prior BCMA-directed therapy, cytopenias, or diminished performance status. Overall, 54 percent had cytokine release syndrome and 11 percent had immune effector cell-associated neurotoxicity syndrome with no fatal events. Forty-two percent had infections, which contributed to death in 5 percent. Partial response or better and very good partial response or better were achieved in 53 and 45 percent, respectively. Estimated median progression-free survival (PFS) was 5.8 months with a median follow-up of 10.1 months; 12-month overall survival was 61 percent. BCMA-directed CAR T-cell therapy in the previous nine months, high disease burden, lymphopenia, and elevated ferritin were independent predictors of less than very good partial response and shorter progression-free survival.
"Our results highlight the complex interplay between real-time clinical parameters and baseline disease features in influencing patient outcomes and suggest that the former may be a more reliable indicator of disease biology than the latter in these patients, but there is still a lot to learn," Razzo said in a statement.
Several authors disclosed ties to the biopharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Aspirin Linked to Lower CRC Recurrence for Molecularly Defined Subgroup
FRIDAY, Sept. 19, 2025 -- Aspirin is associated with a lower incidence of colorectal cancer (CRC) recurrence among certain patients with rectal or colon cancer with somatic...
Cannabis Use Increases Diabetes Risk Nearly Fourfold
FRIDAY, Sept. 19, 2025 -- Cannabis use is associated with a nearly quadrupled risk for developing type 2 diabetes, according to a study presented at the annual meeting of the...
Slightly More Than Half of Pregnant Women With Epilepsy See Neurologist in Year Predelivery
FRIDAY, Sept. 19, 2025 -- Just over half (55 percent) of pregnant women with epilepsy (WWE) saw a neurologist in the year prior to delivery, according to a study presented at the...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.