Skip to main content

Many Ineligible for Clinical Trial Could Benefit From Teclistamab for Multiple Myeloma

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on July 16, 2025.

via HealthDay

WEDNESDAY, July 16, 2025 -- In a study published online July 9 in Blood Cancer Discovery, real-world outcomes are described for teclistamab, a T-cell-engaging bispecific antibody that targets multiple myeloma (MM) cells via the B-cell maturation antigen (BCMA) receptor.

Beatrice M. Razzo, M.D., from the University of Pennsylvania in Philadelphia, and colleagues conducted a retrospective cohort study of postapproval, real-world outcomes with teclistamab in the U.S. MM Immunotherapy Consortium.

The researchers found that 89 percent of the 509 patients would have been ineligible for the MajesTEC-1 trial, mainly due to prior BCMA-directed therapy, cytopenias, or diminished performance status. Overall, 54 percent had cytokine release syndrome and 11 percent had immune effector cell-associated neurotoxicity syndrome with no fatal events. Forty-two percent had infections, which contributed to death in 5 percent. Partial response or better and very good partial response or better were achieved in 53 and 45 percent, respectively. Estimated median progression-free survival (PFS) was 5.8 months with a median follow-up of 10.1 months; 12-month overall survival was 61 percent. BCMA-directed CAR T-cell therapy in the previous nine months, high disease burden, lymphopenia, and elevated ferritin were independent predictors of less than very good partial response and shorter progression-free survival.

"Our results highlight the complex interplay between real-time clinical parameters and baseline disease features in influencing patient outcomes and suggest that the former may be a more reliable indicator of disease biology than the latter in these patients, but there is still a lot to learn," Razzo said in a statement.

Several authors disclosed ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Older Age, Lower Fitness Linked to Atrial Ectopic Burden

FRIDAY, Aug. 29, 2025 -- Age is a significant independent risk factor for atrial ectopic burden (AEB) and ventricular ectopic burden (VEB), according to a study presented at the...

Geriatric Assessment in the Emergency Department Reduces Admission Rates

FRIDAY, Aug. 29, 2025 -- A comprehensive assessment of older adults being seen in the emergency department can help reduce hospital admissions, according to a study published...

2010 to 2023 Saw Decline in Births, Increase in Deaths in the United States

FRIDAY, Aug. 29, 2025 -- From 2010 to 2023, the number of births in the United States declined, and the number of deaths increased, according to the Aug. 27 National Vital...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.