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Many Ineligible for Clinical Trial Could Benefit From Teclistamab for Multiple Myeloma

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on July 16, 2025.

WEDNESDAY, July 16, 2025 -- In a study published online July 9 in Blood Cancer Discovery, real-world outcomes are described for teclistamab, a T-cell-engaging bispecific antibody that targets multiple myeloma (MM) cells via the B-cell maturation antigen (BCMA) receptor.

Beatrice M. Razzo, M.D., from the University of Pennsylvania in Philadelphia, and colleagues conducted a retrospective cohort study of postapproval, real-world outcomes with teclistamab in the U.S. MM Immunotherapy Consortium.

The researchers found that 89 percent of the 509 patients would have been ineligible for the MajesTEC-1 trial, mainly due to prior BCMA-directed therapy, cytopenias, or diminished performance status. Overall, 54 percent had cytokine release syndrome and 11 percent had immune effector cell-associated neurotoxicity syndrome with no fatal events. Forty-two percent had infections, which contributed to death in 5 percent. Partial response or better and very good partial response or better were achieved in 53 and 45 percent, respectively. Estimated median progression-free survival (PFS) was 5.8 months with a median follow-up of 10.1 months; 12-month overall survival was 61 percent. BCMA-directed CAR T-cell therapy in the previous nine months, high disease burden, lymphopenia, and elevated ferritin were independent predictors of less than very good partial response and shorter progression-free survival.

"Our results highlight the complex interplay between real-time clinical parameters and baseline disease features in influencing patient outcomes and suggest that the former may be a more reliable indicator of disease biology than the latter in these patients, but there is still a lot to learn," Razzo said in a statement.

Several authors disclosed ties to the biopharmaceutical industry.

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Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Posted July 2025

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