Gastroesophageal Reflux Disease Tied to Increased Risk for Rheumatoid Arthritis
By Lori Solomon HealthDay Reporter
WEDNESDAY, Aug. 14, 2024 -- Gastroesophageal reflux disease (GERD) increases the risk for rheumatoid arthritis (RA), according to a study published online Aug. 1 in Scientific Reports.
Quan Yuan, from the First Hospital of Jilin University in Changchun, China, and colleagues used Mendelian randomization (MR) to assess the causal relationship between GERD and RA.
The researchers found that MR results suggest a causal effect of the genetic susceptibility of GERD on RA (discovery dataset, inverse variance weighting, odds ratio, 1.41; validation dataset, inverse variance weighting, odds ratio, 1.38). When adjusting for confounding factors between GERD and RA, including smoking quantity, drinking frequency, body mass index, depression, and education attainment, MR analysis results were similar. However, the reverse MR analysis did not show evidence that RA can increase the risk for developing GERD.
"This finding is crucial for deepening our understanding of the pathogenesis of RA and may offer new insights for the prevention and treatment of RA," the authors write. "It also offers a new perspective on preventing the occurrence of GERD in patients with RA. However, based on the results of the reverse MR analysis using the existing dataset, compelling evidence was not found for RA increasing the risk of developing GERD."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
Psoriatic Arthritis Tied to Delays in Diagnosis Compared With Rheumatoid Arthritis
WEDNESDAY, April 30, 2025 -- Patients with psoriatic arthritis (PsA) have delays in diagnosis compared with those with rheumatoid arthritis (RA), according to a study published...
Lower Rates of Symptom Rebound Seen After H. Pylori Eradication in GERD
THURSDAY, March 6, 2025 -- For patients with gastroesophageal reflux disease (GERD), those with Helicobacter pylori infection have significantly lower rates of symptom rebound and...
Overactive Bladder Positively Associated With Arthritis
WEDNESDAY, March 5, 2025 -- Overactive bladder (OAB) is associated with arthritis, with a positive association seen after adjustment for all covariates, according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.