Extracorporeal Blood Purification Can Cut Cardiac Surgery-Associated AKI
By Elana Gotkine HealthDay Reporter
.jpg?width=1200)
FRIDAY, Oct. 11, 2024 -- For patients undergoing nonemergent cardiopulmonary bypass (CPB), use of an extracorporeal blood purification (EBP) device is associated with a lower rate of cardiac surgery-associated acute kidney injury (CSA-AKI), according to a study published online Oct. 9 in the Journal of the American Medical Association to coincide with the annual congress of the European Society of Intensive Care Medicine, held from Oct. 5 to 9 in Barcelona, Spain.
Xosé Pérez-Fernández, Ph.D., from L'Hospitalet de Llobregat in Barcelona, Spain, and colleagues conducted a double-blind, randomized clinical trial in two tertiary hospitals to examine whether use of an EBP device reduces CSA-AKI after CPB. Adults undergoing nonemergent cardiac surgery who were at high risk for CSA-AKI were randomly assigned to receive EBP or standard care (169 and 174 patients, respectively).
The researchers found that the rate of CSA-AKI was 28.4 and 39.7 percent in the EBP and standard-care groups, respectively. In most of the predefined clinical secondary end points or post hoc exploratory end points, there were no significant differences observed. In terms of CSA-AKI reduction, EBP was more effective for patients with chronic kidney disease, diabetes, hypertension, low left ventricular ejection fraction (<40 percent), and lower body mass index (<30 kg/m2) in a sensitivity analysis. The groups did not differ in adverse events.
"The use of a nonselective EBP device connected to the CPB circuit in a nonemergent population of patients undergoing cardiac surgery was associated with a significant reduction of CSA-AKI in the first seven days after the surgical procedure," the authors write.
One author disclosed ties to Exthera and SphingoTec.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted October 2024
Read this next
Overweight Status Appears to Reduce Mortality in Seniors Undergoing Elective Surgery
THURSDAY, Aug. 28, 2025 -- Older adults (aged 65 years and older) with overweight who undergo elective surgery have a lower rate of 30-day all-cause mortality compared with those...
Elevated Circulating Trimethylamine N-Oxide Levels Linked to AAA Risk, Growth Rate
WEDNESDAY, Aug. 27, 2025 -- Elevated circulating trimethylamine N-oxide (TMAO) levels are associated with an increased risk for abdominal aortic aneurysms (AAA) and with the risk...
Incidence of Hemodynamic Valve Deterioration 6.2 Percent After TAVI
TUESDAY, Aug. 26, 2025 -- For patients undergoing transcatheter aortic valve implantation (TAVI), the incidence of one-year hemodynamic valve deterioration (HVD) was 6.2 percent...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.