Candidate Genetic Variants Have Minimal Impact on Opioid Addiction Risk
MONDAY, Jan. 13, 2025 -- Fifteen candidate genetic variants account for only 0.40 percent of variation in opioid use disorder (OUD) risk, according to a study published online Jan. 9 in JAMA Network Open.
Christal N. Davis, Ph.D., from the Crescenz Veterans Affairs Medical Center in Philadelphia, and colleagues examined the utility of 15 genetic variants from an algorithm intended to predict OUD risk in a case-control study using electronic health record data, which were accrued from 452,664 participants with opioid exposure in the Million Veteran Program across the United States.
The researchers found that the 15 candidate genes accounted for 0.40 percent of the variation in OUD risk, while age and sex accounted for 3.27 percent of the variation. Using the 15 variants as predictive factors, the ensemble machine learning model correctly classified 52.83 percent of individuals in an independent testing sample.
"Findings of this case-control study suggest that candidate genetic variants from the approved genetic risk algorithm do not meet standards of reasonable clinical efficacy in assessing risk of opioid use disorder," the authors write. "Because genetic risk models in psychiatry will continue to emerge and could prove clinically useful, it is crucial that researchers and regulatory agencies adopt rigorous standards for developing and evaluating them prior to their application in clinical settings."
Several authors disclosed ties to the biopharmaceutical industry; several authors reported holding relevant patents or having patents pending.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Aspirin Linked to Lower CRC Recurrence for Molecularly Defined Subgroup
FRIDAY, Sept. 19, 2025 -- Aspirin is associated with a lower incidence of colorectal cancer (CRC) recurrence among certain patients with rectal or colon cancer with somatic...
Cannabis Use Increases Diabetes Risk Nearly Fourfold
FRIDAY, Sept. 19, 2025 -- Cannabis use is associated with a nearly quadrupled risk for developing type 2 diabetes, according to a study presented at the annual meeting of the...
Slightly More Than Half of Pregnant Women With Epilepsy See Neurologist in Year Predelivery
FRIDAY, Sept. 19, 2025 -- Just over half (55 percent) of pregnant women with epilepsy (WWE) saw a neurologist in the year prior to delivery, according to a study presented at the...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.