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Generic name: voxelotor [ vox-EL-oh-tor ]
Brand name: Oxbryta
Dosage forms: oral tablet (300 mg; 500 mg), oral tablet, soluble (300 mg)
Drug class: Miscellaneous uncategorized agents

Medically reviewed by on Jun 21, 2023. Written by Cerner Multum.

What is voxelotor?

Voxelotor is used to treat sickle cell disease in adults and children at least 4 years old.

Voxelotor is sometimes given together with another medicine called hydroxyurea.

Voxelotor may also be used for purposes not listed in this medication guide.

Voxelotor side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of voxelotor may include:

  • headache;

  • fever;

  • hives, rash; or

  • stomach pain, nausea, diarrhea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use voxelotor if you are allergic to it.

Tell your doctor if you have ever had:

  • liver problems.

It is not known if voxelotor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using voxelotor, and for at least 2 weeks after your last dose.

How should I take voxelotor?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take voxelotor once per day with or without food.

Tablets: swallow the tablet whole and do not crush, chew, or break it.

Tablets for oral suspension: mix the tablets for oral suspension in room temperature clear liquid, such as water, clear soda, apple juice, clear electrolyte drink, clear flavored drink, or clear sports drink, just before taking it. Do not swallow whole, break, crush, or chew the tablets for oral suspension.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes.

Voxelotor can affect the results of certain blood tests. Tell any doctor who treats you that you are using voxelotor.

You should not stop using voxelotor without your doctor's advice.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Voxelotor dosing information

Usual Adult Dose for Sickle Cell Anemia:

1500 mg orally once a day

-This drug may be given with or without hydroxyurea.

Use: For the treatment of sickle cell disease.

Usual Pediatric Dose for Sickle Cell Anemia:

4 to less than 12 years:
-Weight: 10 to less than 20 kg: 600 mg orally once a day
-Weight: 20 to less than 40 kg: 900 mg orally once a day
-Weight 40 kg or greater: 1500 mg orally once a day

12 years or older: 1500 mg orally once a day

-This drug may be given with or without hydroxyurea.

Use: For the treatment of sickle cell disease in patients 4 years or older.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking voxelotor?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect voxelotor?

Tell your doctor about all your current medicines. Many drugs can affect voxelotor, especially:

This list is not complete and many other drugs may affect voxelotor. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.