Pozelimab

Generic name: pozelimab [ poe-ZEL-i-mab ]
Brand name: Veopoz
Dosage form: injectable solution (bbfg 200 mg/mL)
Drug class: Selective immunosuppressants

Medically reviewed by Drugs.com on Dec 19, 2023. Written by Cerner Multum.

What is pozelimab?

Pozelimab is for use in adults and children at least 1 year old to treat complement hyperactivation, angiopathic thrombosis, protein losing enteropathy (CHAPLE) syndrome.

Pozelimab may also be used for purposes not listed in this medication guide.

Pozelimab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Read the Patient Wallet Card about the symptoms of meningococcal or other infections and learn what symptoms to watch for. Keep the card with you at all times.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

• fever, chills, sore throat;

• headache, neck stiffness, increased sensitivity to light;

• nausea, vomiting;

• confusion, drowsiness;

• mouth sores, red or swollen gums;

• pale skin, easy bruising, unusual bleeding; or

• chest discomfort, wheezing, dry cough or hack, rapid weight loss.

Common side effects of pozelimab may include:

• hair loss;

• bone fracture;

• itchy, raised red patches of skin; or

• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

You may get infections more easily, even serious or fatal infections. Call your doctor if you have flu symptoms, cough, night sweats, headache, neck stiffness, increased sensitivity to light, confusion, or vision problems.

Make sure you are current on all vaccines before you start using pozelimab. Talk to your doctor if you are not current on your vaccines.

Before taking this medicine

You should not use pozelimab if you have a meningococcal infection.

Tell your doctor if you have:

• an infection or fever.

Make sure you are current on all vaccines before you start using pozelimab. Talk to your doctor if you are not current on your vaccines.

Tell your doctor if you are pregnant or breastfeeding.

How is pozelimab given?

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Pozelimab is injected into a vein and also under the skin by a healthcare provider.

You will be watched for a short time to make sure you do not have an allergic reaction.

You may need medical tests.

Pozelimab dosing information

Usual Adult Dose for CHAPLE Syndrome:

Initial dose: Day 1: 30 mg/kg by intravenous infusion over a minimum of 1 hour
Maintenance dose: Day 8 and thereafter: 10 mg/kg subcutaneously once a week
Maximum dose: 800 mg once a week

Comments:
-According to Advisory Committee on Immunization Practices (ACIP) guidelines, meningococcal vaccination should be completed at least 2 weeks before administering the first dose of this drug.
-The maintenance dosage may be increased to 12 mg/kg once a week if there is insufficient clinical response after at least three weekly doses.
-Doses greater than 400 mg require two injections.
-Do not exceed the maximum infusion rate of 1000 mg/hour.
-Monitor for 30 minutes after completing the infusion.
-This drug has not been studied in the geriatric population.

Use: For the treatment of adult patients with CD55-deficient protein-losing enteropathy (PLE), also known as CHAPLE disease

Usual Pediatric Dose for CHAPLE Syndrome:

1 year or older:
Initial dose: Day 1: 30 mg/kg by intravenous infusion over a minimum of 1 hour
Maintenance dose: Day 8 and thereafter: 10 mg/kg subcutaneously once a week
Maximum dose: 800 mg once a week

Comments:
-According to ACIP guidelines, meningococcal vaccination should be completed at least 2 weeks before administering the first dose of this drug.
-The maintenance dosage may be increased to 12 mg/kg once a week if there is insufficient clinical response after at least three weekly doses.
-Doses greater than 400 mg require two injections.
-Do not exceed the maximum infusion rate of 1000 mg/hour.
-Monitor for 30 minutes after completing the infusion.

Use: For the treatment of pediatric patients 1 year of age and older with CD55-deficient protein-losing enteropathy (PLE), also known as CHAPLE disease

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your pozelimab injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving pozelimab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect pozelimab?

Tell your doctor about all your other medicines, especially:

• intravenous immunoglobulin.

This list is not complete. Other drugs may affect pozelimab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Pozelimab Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for pozelimab.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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