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Generic name: docusate and sennaDOK-yoo-sate-and-SEN-a ]
Brand names: Colace 2-in-1, Senexon-S, Senna Plus, Senna S, Senna-Time S, ... show all 11 brands
Drug class: Laxatives

Medically reviewed by on Aug 7, 2023. Written by Cerner Multum.

What is Peri-Colace?

Docusate is a stool softener. Senna is a laxative.

Peri-Colace is a combination medicine used to treat occasional constipation.

Peri-Colace may also be used for purposes not listed in this medication guide.

Peri-Colace side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Peri-Colace may cause serious side effects. Stop using Peri-Colace and call your doctor at once if you have:

Common side effects of Peri-Colace may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Use exactly as directed on the label, or as prescribed by your doctor.

Before taking this medicine

You should not use Peri-Colace if you are allergic to docusate or senna, or if you are also taking mineral oil.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give this medicine to a child younger than 2 years old without medical advice.

How should I use Peri-Colace?

Use exactly as directed on the label, or as prescribed by your doctor.

Take Peri-Colace with a full glass of water.

It may be best to take this medicine at night or at bedtime. Peri-Colace should cause you to have a bowel movement within 6 to 12 hours.

Do not take Peri-Colace for longer than 7 days in a row, unless your doctor tells you to.

Call your doctor if your constipation does not improve or if it gets worse after taking Peri-Colace.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since Peri-Colace is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, stomach pain, or diarrhea.

What should I avoid while using Peri-Colace?

Ask a doctor or pharmacist before using any other laxative or other stool softener that may contain ingredients similar to docusate or senna.

What other drugs will affect Peri-Colace?

Other drugs may affect Peri-Colace, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.