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Neutral Sodium Fluoride Rinse

Generic name: fluoride topicalFLOR-ide-TOP-i-kal ]
Brand names: ACT Fluoride Rinse, Biotene, Dentagel, Fluorigard, Gel-Kam, ... show all 11 brands
Drug class: Mouth and throat products

Medically reviewed by on Aug 4, 2023. Written by Cerner Multum.

What is Neutral Sodium Fluoride Rinse?

There are many brands and forms of fluoride topical available. Not all brands are listed on this leaflet.

Neutral Sodium Fluoride Rinse is used to help prevent cavities, tooth decay, and gum disease. This medicine can also help strengthen tooth enamel, remove plaque bacteria from teeth and gums, and decrease painful tooth sensitivity.

Fluoride may also be used for purposes not listed in this medication guide.

Neutral Sodium Fluoride Rinse side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor if your sensitivity does not improve, or if it gets worse.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on the label and package, or use exactly as prescribed by your dentist or doctor.

Before taking this medicine

You should not use Neutral Sodium Fluoride Rinse if you are allergic to it.

If you are using a prescription toothpaste, tell your dentist or doctor if you have kidney disease.

Ask a doctor before using Neutral Sodium Fluoride Rinse if you are pregnant or breastfeeding.

Do not use Neutral Sodium Fluoride Rinse in a child without the advice of a doctor or dentist. Some forms of fluoride topical should not be used in children of certain ages.

How should I use Neutral Sodium Fluoride Rinse?

Read and carefully follow all Instructions for Use on the label of your Neutral Sodium Fluoride Rinse product. Ask your dentist or call the product manufacturer if you do not understand these instructions.

Do not swallow Neutral Sodium Fluoride Rinse. It is for use only on your teeth and gums.

Fluoride preventive treatment gel should not be used as a toothpaste for regular brushing.

Do not allow a young child to use Neutral Sodium Fluoride Rinse without help from an adult.

Neutral Sodium Fluoride Rinse rinse or gel can stain your teeth. Regular brushing can help prevent this.

Do not eat or drink anything or rinse your mouth for 30 minutes after using Neutral Sodium Fluoride Rinse.

Do not use Neutral Sodium Fluoride Rinse rinse to treat tooth sensitivity for longer than 4 weeks unless your dentist or doctor tells you to.

Stop using Neutral Sodium Fluoride Rinse and call your dentist or doctor if your tooth sensitivity does not improve, or if it gets worse.

Store at room temperature away from moisture and heat. Do not freeze. Avoid extreme heat.

What happens if I miss a dose?

Use the dose as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may result if you swallow large amounts of fluoride while using it.

Overdose symptoms may include nausea, vomiting, stomach pain, diarrhea, burning in the mouth, and sore tongue.

More serious overdose symptoms may include severe stomach cramps and coughing up blood.

What should I avoid while using Neutral Sodium Fluoride Rinse?

Avoid swallowing Neutral Sodium Fluoride Rinse. Spit it out after use.

What other drugs will affect Neutral Sodium Fluoride Rinse?

Neutral Sodium Fluoride Rinse used in the mouth is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.