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Kefzol (injection)

Generic Name: cefazolin (injection) (sef A zoe lin)
Brand Name: Ancef, Kefzol

Medically reviewed by Drugs.com on Apr 19, 2019 – Written by Cerner Multum

What is Kefzol?

Kefzol is a cephalosporin (SEF a low spor in) antibiotic that is is used to treat bacterial infections, including severe or life-threatening forms. This medicine is also used to help prevent infection in people having certain types of surgery.

Kefzol may also be used for purposes not listed in this medication guide.

Important Information

You should not use Kefzol if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic (Omnicef, Keflex, and others).

Before taking this medicine

You should not take Kefzol if you are allergic to Kefzol or to other cephalosporin antibiotics, such as:

Tell your doctor if you have ever had:

  • kidney disease;

  • liver disease;

  • a stomach or intestinal disorder such as colitis; or

  • an allergy to any type of penicillin.

Tell your doctor if you are pregnant or breastfeeding.

How is Kefzol given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Kefzol is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Kefzol may need to be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Kefzol will not treat a viral infection such as the flu or a common cold.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Kefzol.

Store unmixed Kefzol at room temperature, away from moisture, heat, and light.

After mixing Kefzol with a diluent, store the mixture in the refrigerator. Do not freeze.

Take the mixture out of the refrigerator and allow it to reach room temperature before injecting your dose. Mixed medicine must be used within a certain number of days once it reaches room temperature. Carefully follow all mixing and storage instructions for this medicine.

Do not use the medicine if it has changed colors or has particles in it. Call your pharmacist for new medication.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Kefzol.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Kefzol?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Kefzol side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

  • white patches or sores inside your mouth or on your lips;

  • fever, swollen glands, rash or itching, joint pain, or general ill feeling;

  • seizure (convulsions); or

  • liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Kefzol?

Other drugs may affect Kefzol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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