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Cefazolin Pregnancy and Breastfeeding Warnings

Cefazolin is also known as: Ancef, Kefzol

Cefazolin Pregnancy Warnings

A positive direct and indirect antiglobulin (Coombs) test may occur in neonates of mothers who received cephalosporins before delivery.

Cefazolin has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Levels measured in cord blood prior to caesarean section have been one-fourth to one-third of maternal levels. No adverse fetal effects have been reported. Cefazolin should only be given during pregnancy when need has been clearly established.

See references

Cefazolin Breastfeeding Warnings

Cefazolin is excreted into human milk in small amounts. Cefazolin is considered compatible with breast-feeding by the American Academy of Pediatrics.

See references

References for pregnancy information

  1. "Product Information. Ancef (cefazolin)." SmithKline Beecham, Philadelphia, PA.
  2. "Product Information. Kefzol (cefazolin)." Lilly, Eli and Company, Indianapolis, IN.
  3. Fiore Mitchell T, Pearlman MD, Chapman RL, Bhatt-Mehta V, Faix RG "Maternal and transplacental pharmacokinetics of cefazolin." Obstet Gynecol 98 (2001): 1075-9
  4. Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J "Use of cephalosporins during pregnancy and in the presence of congenital abnormalities: A population-based, case-control study." Am J Obstet Gynecol 184 (2001): 1289-96
  5. Heikkila A, Erkkola R "Review of beta-lactam antibiotics in pregnancy - the need for adjustment of dosage schedules." Clin Pharmacokinet 27 (1994): 49-62

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. "Product Information. Kefzol (cefazolin)." Lilly, Eli and Company, Indianapolis, IN.
  3. Yoshioka H, Cho K, Takimoto M, et al "Transfer of cefazolin into human milk." J Pediatr 94 (1979): 151-2
  4. "Product Information. Ancef (cefazolin)." SmithKline Beecham, Philadelphia, PA.

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