How long does an Ultomiris infusion take?

In general, minimum intravenous (IV) infusion times for Ultomiris (ravulizumab-cwvz) can range from 0.4 hours to 3.8 hours. The infusion time is based on the patient’s weight, the prescribed dose and if it is a loading dose or maintenance dose. Patients are also monitored for at least one hour after the IV infusion for allergic-type infusion reactions.

• The minimum time for a loading dose infusion of Ultomiris 100 mg/mL (3 mL and 11 mL vials) ranges from 0.4 to 1.4 hours. The minimum time for a maintenance dose infusion of Ultomiris 100 mg/mL (3 mL and 11 mL vials) ranges from 0.5 to 1.3 hours.
• The minimum time for a loading dose infusion of Ultomiris 10 mg/mL (30 mL vial) ranges from 1.3 to 3.8 hours. The minimum time for a maintenance dose infusion of Ultomiris 10 mg/mL (30 mL vial) ranges from 1.9 to 3.3 hours.
• Do not mix Ultomiris 100 mg/mL (3 mL and 11 mL vials) and 10 mg/mL (30 mL vial) concentrations together.

Ultomiris is given through a vein as an intravenous (IV) infusion or also as a subcutaneous (under the skin) injection. Refer to the manufacturer’s product labeling for the tables detailing administration of Ultomiris.

How often are Ultomiris infusions given?

The first two infusions are usually given 2 weeks apart, followed by an infusion once every 4 or 8 weeks, based on body weight. Only use Ultomiris as directed by your doctor. If you miss an appointment for your Ultomiris infusion, call your doctor right away.

Ultomiris is approved by the FDA for the treatment of:

• paroxysmal nocturnal hemoglobinuria (PNH)
• atypical hemolytic uremic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy (TMA)
• generalized myasthenia gravis (gMG)
• neuromyelitis optica spectrum disorder (NMOSD)

This is not all the information you need to know about Ultomiris (ravulizumab) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

See also:

Related medical questions

• How does Ultomiris compare to Soliris for PNH?
• How long does it take for Ultomiris to work?
• How does Ultomiris work for myasthenia gravis?

Drug information

• Ultomiris Information for Consumers
• Ultomiris prescribing info & package insert (for Health Professionals)
• Side Effects of Ultomiris (detailed)
• Ultomiris user reviews (8)

Related support groups

• Ultomiris (4 questions, 3 members)

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