Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Adriamycin RDF (doxorubicin)
- Oncovin (vincristine)
Interactions between your drugs
DOXOrubicin vinCRIStine
Applies to: Adriamycin RDF (doxorubicin), Oncovin (vincristine)
Concurrent administration of vincristine and doxorubicin may lead to an earlier onset and/or an increased severity of side effects. The mechanism is the inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and doxorubicin are used concomitantly, caution and close observation are advised.
References (2)
- Zhou-Pan XR, Seree E, Zhou XJ, et al. (1993) "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res, 53, p. 5121-6
- (2001) "Product Information. Oncovin (vincristine)." Lilly, Eli and Company
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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