Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Attruby (acoramidis)
- enzalutamide
Interactions between your drugs
enzalutamide acoramidis
Applies to: enzalutamide, Attruby (acoramidis)
GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 isoenzymes can potentially decrease the plasma concentrations of acoramidis. In vitro, acoramidis is a substrate of multiple uridine diphosphoglucuronate-glucuronosyltransferase (UGT) enzymes and is primarily metabolized by UGT enzyme-mediated glucuronidation. While acoramidis is not metabolized by CYP450 3A4, strong CYP450 3A4 inducers can also induce UGT enzymes.
MANAGEMENT: According to the manufacturer, concomitant use of acoramidis with potent inducers of CYP450 3A4 enzymes should generally be avoided due to the potential for reduced efficacy.
References (1)
- (2024) "Product Information. Attruby (acoramidis)." BridgeBio Pharma, Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Acoramidis
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Learn more
Further information
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