Drug Interaction Report
1 drug interaction and 3 additional warnings found for the following 2 drugs:
- trofinetide
- tucatinib
Drug interactions
Moderate drug interactions
Moderate:tucatinib trofinetide
Applies to: tucatinib, trofinetide
Trofinetide may increase the blood levels and effects of tucatinib.
Talk to your doctor if you have any questions or concerns.
You may need more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Disease interactions
3 potential interactionsApplies to: 3 conditions, including Hyperkalemia, Liver Disease, and Renal Dysfunction.
Hyperkalemia
Moderate:tucatinib
Tucatinib has a moderate potential interaction with Hyperkalemia.
Tucatinib contains 60.6 mg potassium per 300 mg dose. This should be taken into consideration especially in patients with hyperkalemia or impaired kidney function who are on a controlled potassium diet.
Liver Disease
Moderate:tucatinib
Tucatinib has a moderate potential interaction with Liver Disease.
Tucatinib is a hepatotoxic drug. Additionally, its exposure is increased in patients with severe hepatic impairment. This is the reason why the dosage must be reduced in these patients (Child-Pugh C). Consult the manufacturers prescribing information for details on dosage modification.
Renal Dysfunction
Moderate:tucatinib
Tucatinib has a moderate potential interaction with Renal Dysfunction.
Tucatinib contains 60.6 mg potassium per 300 mg dose. This should be taken into consideration especially in patients with hyperkalemia or impaired kidney function who are on a controlled potassium diet.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.