Drug Interaction Report

MONITOR: Coadministration with eye drops containing corticosteroids may potentiate the immunosuppressant effects of cyclosporine eye drops.

MANAGEMENT: Caution is recommended if corticosteroid-containing eye drops and cyclosporine-containing eye drops are used concomitantly. Eye examination at 6-monthly intervals are recommended if cyclosporine eye drops are intended for long-term use.

ADJUST DOSE: In-vivo studies have demonstrated that the absorption of bromfenac is greatly reduced if the drug is taken within three and one-half hours following a high fat meal. The concomitant administration of a high fat meal has led to a 75% reduction in peak plasma concentrations and a 60% reduction in total area under the curve. The mechanism has not been described.

MANAGEMENT: An increased dosage of bromfenac (from 25 to 50 mg) may be needed if a high fat meal is consumed. The clinician may want to warn the patient about subtherapeutic analgesic effects if high fat meals are regularly consumed.