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Drug Interaction Report

27 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

atropine chlorpheniramine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using atropine together with chlorpheniramine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

atropine phenylephrine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Atropine may increase the effects of phenylephrine on your blood pressure and heart rate. Before receiving these medications, you should let your doctor know if you have high blood pressure or heart disease. You may not be able to use one or both of these medications, or you may need closer monitoring by your doctor in order to use these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

atropine hyoscyamine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using atropine together with hyoscyamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

atropine scopolamine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using atropine together with scopolamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine dextromethorphan

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)

Using chlorpheniramine together with dextromethorphan may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine hyoscyamine

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using chlorpheniramine together with hyoscyamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine scopolamine

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using chlorpheniramine together with scopolamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

dextromethorphan scopolamine

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using dextromethorphan together with scopolamine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine phenylpropanolamine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Both phenylephrine and phenylpropanolamine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine hyoscyamine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Hyoscyamine may increase the effects of phenylephrine on your blood pressure and heart rate. Before receiving these medications, you should let your doctor know if you have high blood pressure or heart disease. You may not be able to use one or both of these medications, or you may need closer monitoring by your doctor in order to use these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine scopolamine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Scopolamine may increase the effects of phenylephrine on your blood pressure and heart rate. Before receiving these medications, you should let your doctor know if you have high blood pressure or heart disease. You may not be able to use one or both of these medications, or you may need closer monitoring by your doctor in order to use these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

hyoscyamine scopolamine

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using hyoscyamine together with scopolamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

acetaminophen atropine

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Information for this minor interaction is available on the professional version.

Minor

acetaminophen hyoscyamine

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Information for this minor interaction is available on the professional version.

Minor

acetaminophen scopolamine

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Major

acetaminophen food

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)

Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

chlorpheniramine food

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlorpheniramine. Do not use more than the recommended dose of chlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

dextromethorphan food

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)

Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

phenylpropanolamine food

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Using phenylpropanolamine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. In addition, you may also be more likely to experience nervous system side effects such as dizziness, drowsiness, depression, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with phenylpropanolamine. Do not use more than the recommended dose of phenylpropanolamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

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Moderate

atropine food

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Ask your doctor before using atropine together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking atropine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

hyoscyamine food

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Ask your doctor before using hyoscyamine together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking hyoscyamine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

scopolamine food

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Ask your doctor before using scopolamine together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking scopolamine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine food

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Both phenylephrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylpropanolamine food

Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Both phenylpropanolamine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

scopolamine food

Applies to: Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Antihistamines

Therapeutic duplication

The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antihistamines' category:

  • Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
  • Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

Duplication

Decongestants

Therapeutic duplication

The recommended maximum number of medicines in the 'decongestants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'decongestants' category:

  • Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
  • Rolatuss-SR (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.