Drug Interaction Report

Cholestyramine may interfere with the absorption of obeticholic acid and reduce its levels in the bloodstream. This may make the medication less effective in treating your condition. You should take obeticholic acid at least 4 hours before or 4 hours after cholestyramine, or separate the dosing times by as much as possible if a 4 hour interval is not achievable. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Cholestyramine may interfere with the absorption of certain vitamins such as A, D, E and K. Therefore, it is recommended that you take multivitamin with minerals at least 1 hour before or 4 to 6 hours after cholestyramine to minimize the risk of interaction. Talk to your doctor or pharmacist if you have questions on how to take these or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.