Drug Interaction Report

Rufinamide may reduce the blood levels of isavuconazonium. In some cases, this may make the medication less effective. Using rufinamide with isavuconazonium may also increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. Talk to your doctor if you have any questions or concerns. Your doctor may already be able to prescribe alternatives that do not interact, or may be aware of the risks but has determined that this is the best course of treatment for you, and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food can enhance the levels of rufinamide in your body. To ensure maximal oral absorption, rufinamide should be administered with or immediately after a meal. This will make it easier for your body to absorb the medication. Do not drink alcohol while you are taking rufinamide. Alcohol can increase some of the side effects including drowsiness or dizziness. Talk to your doctor or pharmacist if you have any questions or concerns.