Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- balsam peru / benzyl benzoate / bismuth resorcin / bismuth subgallate / zinc oxide
- omadacycline
Interactions between your drugs
bismuth subgallate omadacycline
Applies to: balsam peru / benzyl benzoate / bismuth resorcin / bismuth subgallate / zinc oxide, omadacycline
ADJUST DOSING INTERVAL: Concomitant administration of bismuth-containing medications may impair the absorption of oral tetracyclines. The interaction has been studied with tetracycline and doxycycline. The proposed mechanism is chelation of tetracyclines by bismuth.
MANAGEMENT: Administration of a tetracycline and bismuth-containing preparation should either be avoided or separated by two to three hours. However, this precautionary measure is not considered necessary in treatment regimens where bismuth may be given in combination with tetracycline and other medications for the eradication of Helicobacter pylori infection, as the relative contribution of systemic versus local antimicrobial activity against Helicobacter pylori has not been established.
References (5)
- Ericsson CD, Feldman S, Pickering LK, Cleary TG (1982) "Influence of subsalicylate bismuth on absorption of doxycycline." JAMA, 247, p. 2266-7
- Albert KS, Welch RD, DeSante KA, DiSanto AR (1979) "Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture." J Pharm Sci, 68, p. 586-8
- (2018) "Product Information. Seysara (sarecycline)." Allergan Inc
- (2018) "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc.
- (2025) "Product Information. Pylera (bismuth subcitrate potassium/metronidazole/tetracycline)." H2-Pharma LLC
Drug and food/lifestyle interactions
omadacycline food/lifestyle
Applies to: omadacycline
ADJUST DOSING INTERVAL: Administration with food, particularly dairy products, may reduce the absorption of omadacycline. The calcium content of these foods may form nonabsorbable chelates with omadacycline.
MANAGEMENT: Omadacycline should be administered at least 2 hours before (4 hours for dairy products) or 4 hours after meals.
References (1)
- (2018) "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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