Drug Interaction Report

Everolimus may increase the blood levels and effects of gepirone. This may increase the risk and or severity of side effects such as a change in the electrical activity of your heart called QT prolongation, dizziness, nausea, headache, trouble sleeping, stomach pain, and/or upset stomach. Seek immediate medical attention if you experience an irregular heartbeat, palpitations, shortness of breath, dizziness, lightheadedness, and/or fainting as these could be symptoms of an uncommon, but potentially life-threatening heart rhythm resulting from QT prolongation. You may need a dose adjustment or more frequent monitoring to safely use both medications. Talk to your doctor if you have any questions or are experiencing any particularly bothersome side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit juice can increase the blood levels and effects of everolimus. You should not drink grapefruit juice or eat grapefruits during your treatment with everolimus. Orange juice is not expected to interact.

Food helps with the absorption of gepirone into the blood stream. You should take this medication with food at about the same time every day. You should not consume grapefruit or grapefruit products while taking this medication as they can increase the blood levels of gepirone in your body, putting you at a higher risk of serious side effects like serotonin syndrome or a change in the electrical activity of your heart called QT prolongation. Seek immediate medical attention if you experience any of the following signs or symptoms of these potentially life-threatening side effects: irregular or fast heartbeat, dizziness, lightheadedness, fainting, agitation, confusion, sweating, flushing, changes in blood pressure, seizures, hallucinations, or a loss of coordination. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.