Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Cognex (tacrine)
- ibuprofen
Interactions between your drugs
ibuprofen tacrine
Applies to: ibuprofen, Cognex (tacrine)
An isolated case has been reported in which delirium was associated with the combined use of tacrine and ibuprofen. The mechanism of this interaction has not been determined. When tacrine and ibuprofen are used together, clinical monitoring for evidence of delirium may be warranted.
References (1)
- Hooten WM, Pearlson G (1996) "Delirium caused by tacrine and ibuprofen interaction." Am J Psychiatry, 153, p. 842
Drug and food interactions
ibuprofen food
Applies to: ibuprofen
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References (1)
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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