Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- succimer
- TechneScan HDP (oxidronate)
Interactions between your drugs
succimer oxidronate
Applies to: succimer, TechneScan HDP (oxidronate)
MONITOR: Administration of technetium (Tc 99m) oxidronate after chelating agents, diphosphonates, tetracyclines, or iron containing drugs may reduce the quality of the scintigraphic procedure by decreasing the accumulation of Tc 99m oxidronate in skeletal bone. The exact mechanism of the interaction is unknown; however, it may be related to the effects of the interacting drugs on bone homeostasis.
MANAGEMENT: Proceed with caution if chelating agents, diphosphonates, tetracyclines, and iron-containing drugs are used prior to technetium (Tc 99m) oxidronate. The quality of the resulting imaging may be reduced.
References (7)
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
- (2018) "Product Information. TechneScan HDP (oxidronate)." Curium Pharmaceuticals
- (2023) "Product Information. Technescan HDP (oxidronate)." Landauer Radiopharmaceuticals Pty Ltd
- (2021) "Product Information. HDP (Radpharm) (oxidronate)." Global Medical Solutions Pty Limited t/a Radpharm Scientific
- (2023) "Product Information. Technescan HDP Kit (oxidronate)." Curium Pharma UK Ltd
- Warner AJ, Hathaway-Schrader JD, Lubker R, Davies C, Novince CM (2023) Tetracyclines and bone: unclear actions with potentially lasting effects. https://www.sciencedirect.com/science/article/abs/pii/S8756328222000539
- Balogh E, Paragh G, Jeney V (2023) Influence of iron on bone homeostasis. https://www.mdpi.com/1424-8247/11/4/107
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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