Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Ammonul (sodium benzoate / sodium phenylacetate)
- probenecid
Interactions between your drugs
probenecid sodium phenylacetate
Applies to: probenecid, Ammonul (sodium benzoate / sodium phenylacetate)
GENERALLY AVOID: Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect the renal excretion of phenylacetylglutamine and hippurate, the byproducts formed when sodium phenylacetate and sodium benzoate are administered for the treatment of acute hyperammonemia in patients with urea cycle disorders. Since phenylacetylglutamine and hippurate serve as vehicles to reduce waste nitrogen levels in such patients, adequate renal excretion is necessary to treat hyperammonemia and reduce the risk of glutamine-induced neurotoxicity.
MANAGEMENT: Although the interaction is theoretical and no data are available, it may be appropriate to avoid using probenecid during treatment of acute hyperammonemia in patients with urea cycle disorders due to the urgent nature of the condition. Uncontrolled hyperammonemia can rapidly result in brain damage or death.
References (1)
- (2005) "Product Information. Ammonul (sodium benzoate-sodium phenylacetate)." Ucyclyd Pharma
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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