Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Rituxan (rituximab)
- zilucoplan
Interactions between your drugs
riTUXimab zilucoplan
Applies to: Rituxan (rituximab), zilucoplan
Consumer information for this interaction is not currently available.
MONITOR: Theoretically, the complement inhibitors eculizumab, ravulizumab, and zilucopan may reduce the complement-dependent pharmacodynamic effects of rituximab. The proposed mechanism is related to the potential inhibitory effect of complement inhibitors on complement-dependent cytotoxicity of rituximab. However, clinical data evaluating the interaction are not available and the significance of this effect is unknown.
MANAGEMENT: Until more information is available, caution and closer monitoring for decreased efficacy of rituximab is advised if the complement inhibitors eculizumab, ravulizumab, or zilucopan are used concurrently.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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