Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Mestinon (pyridostigmine)
- methacholine
Interactions between your drugs
pyRIDostigmine methacholine
Applies to: Mestinon (pyridostigmine), methacholine
MONITOR: Additive cholinergic effects may occur when methacholine is coadministered with cholinesterase inhibitors. Methacholine is a cholinergic agonist that is hydrolyzed by cholinesterases, and concomitant use of cholinesterase inhibitors may decrease methacholine inactivation, thereby increasing the risk of cholinergic toxicity.
MANAGEMENT: Caution is advised when methacholine is coadministered with cholinesterase inhibitors. Patients should be monitored for increased cholinergic effects and potential toxicity.
References (2)
- (2020) "Product Information. Provocholine (methacholine)." Galen Ltd
- (2022) "Product Information. Provocholine (methacholine)." Methapharm Inc, SUPPL-26
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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