Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- milk thistle
- raloxifene
Interactions between your drugs
raloxifene milk thistle
Applies to: raloxifene, milk thistle
MONITOR: Coadministration with milk thistle constituents silibinin and silymarin may increase raloxifene systemic exposure (AUC). The mechanism involves inhibition of raloxifene glucuronidation in the intestines by milk thistle flavonolignans silybin A and silybin B. Silibinin and silymarin were predicted to increase raloxifene AUC by 4- to 5-fold in a study that used human intestinal microsomes and human embryonic kidney cell lysates.
MANAGEMENT: Patients should be monitored for adverse effects from raloxifene if coadministered with milk thistle or its constituents.
References (1)
- Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF (2015) "Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction." Drug Metab Dispos, 43, p. 1353-9
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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