Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- methylene blue
- viloxazine
Interactions between your drugs
methylene blue viloxazine
Applies to: methylene blue, viloxazine
CONTRAINDICATED: Selective norepinephrine reuptake inhibitors (SNRIs) may precipitate severe hypertensive reactions and potentially life-threatening hypertensive crisis in patients treated with monoamine oxidase inhibitors (MAOIs). The mechanism involves a synergistic sympathomimetic effect due to enhanced norepinephrine storage in adrenergic neurons (MAOI activity) and decreased reuptake of norepinephrine in adrenergic nerve endings (SNRI activity).
MANAGEMENT: Selective norepinephrine reuptake inhibitors should not be used concurrently with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with SNRIs.
References (5)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Pharmaceutical Society of Australia (2006) APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp
- Cerner Multum, Inc. "Australian Product Information."
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
- (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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