Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- methdilazine
- mibefradil
Interactions between your drugs
methdilazine mibefradil
Applies to: methdilazine, mibefradil
MONITOR: Based on in vitro inhibition data, coadministration with mibefradil may increase the plasma concentrations of drugs that are substrates of CYP450 2D6 and/or 3A4. The mechanism is decreased clearance due to inhibition of these isoenzymes by mibefradil.
MANAGEMENT: Caution is advised when mibefradil is used concomitantly with drugs that undergo metabolism by CYP450 2D6 and/or 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever mibefradil is added to or withdrawn from therapy.
References (2)
- (2001) "Product Information. Posicor (mibefradil)." Roche Laboratories
- Varis T, Backman JT, Kivisto KT, Neuvonen PJ (2000) "Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone." Clin Pharmacol Ther, 67, p. 215-21
Drug and food interactions
methdilazine food
Applies to: methdilazine
GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.
References (2)
- Lutz EG (1976) "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA, 236, p. 2422-3
- Freed E (1981) "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust, 2, p. 44-5
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Botox
Botox is used to treat chronic migraines, excessive sweating, bladder conditions, eye muscle ...
Allegra
Allegra (fexofenadine) is an antihistamine used to treat the symptoms of hay fever and other ...
Allegra Allergy
Allegra Allergy is used for allergic rhinitis, allergies
Allegra ODT
Allegra ODT is used for allergic rhinitis, allergies, urticaria
Aller-Chlor
Aller-Chlor is used for allergic reactions, allergic rhinitis, cold symptoms, urticaria
Aller-Ease
Aller-Ease is used for allergic rhinitis, allergies, urticaria
Allergy Relief
Allergy Relief is used for allergic reactions, allergic rhinitis, cold symptoms, urticaria
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.