Drug Interaction Report

MONITOR: An increased incidence (12.6%) of acute, atypical reactions to iodinated contrast media has been observed in patients who have been previously treated with interleukin-2. The cause and mechanism have not been established. Symptoms generally have an onset of 1 to 4 hours and may include nausea, vomiting, diarrhea, fever, chills, flu-like symptoms, joint pain, rash, pruritus, hypotension, edema, and oliguria. Reactions have typically been reported when patients received iodinated contrast media within 4 weeks after the last dose of interleukin-2, but have also occurred several months after interleukin treatment.

MANAGEMENT: Patients should be monitored for adverse reactions after receiving iodinated contrast media, and symptomatic treatment initiated as clinically appropriate.