Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- histamine phosphate
- Pro-Med (promethazine)
Interactions between your drugs
promethazine histamine phosphate
Applies to: Pro-Med (promethazine), histamine phosphate
MONITOR: Antihistamines may suppress the patient's response to histamine phosphate. The length of suppression varies and is dependent on the patient, type of antihistamine, and the duration of antihistamine therapy. The duration of suppression may range from 24 hours with chlorpheniramine or up to several weeks with second-generation antihistamines.
MANAGEMENT: Clinicians should be aware of the potential for falsely insignificant or false-negative results when administering histamine phosphate to patients treated with antihistamines.
References (1)
- (2002) "Product Information. Histatrol (histamine phosphate)." Center Laboratories
Drug and food interactions
promethazine food
Applies to: Pro-Med (promethazine)
GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.
References (2)
- Lutz EG (1976) "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA, 236, p. 2422-3
- Freed E (1981) "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust, 2, p. 44-5
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Botox
Botox is used to treat chronic migraines, excessive sweating, bladder conditions, eye muscle ...
Accutane
Accutane (isotretinoin) is a form of vitamin A and is used to treat severe nodular acne. Includes ...
Adakveo
Adakveo (crizanlizumab-tmca) is used for the prevention of vasoocclusive crises (VOCs) in patients ...
Ammonul
Ammonul is used to treat a condition caused by too much ammonia in the blood. Includes Ammonul side ...
Amnesteem
Amnesteem is used for acne, acute nonlymphocytic leukemia, granuloma annulare, rosacea
Amondys 45
Amondys 45 (casimersen) is used to treat Duchenne muscular dystrophy (DMD) with a genetic mutation ...
Amphadase
Amphadase (hyaluronidase) increases the absorption of other injected medicines or fluids. Includes ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.