Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Infugem (gemcitabine)
- necitumumab
Interactions between your drugs
gemcitabine necitumumab
Applies to: Infugem (gemcitabine), necitumumab
Coadministration with necitumumab may increase the plasma concentrations of gemcitabine. The mechanism of interaction has not been described. In 12 study patients with advanced solid tumors who received gemcitabine and cisplatin with necitumumab, dose-normalized mean gemcitabine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 63% and 22%, respectively, compared to administration of gemcitabine and cisplatin alone. Mean AUCs of cisplatin and necitumumab were unchanged.
References (1)
- (2015) "Product Information. Portrazza (necitumumab)." Eli Lilly and Company
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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