Povidone K25
Medically reviewed by Drugs.com. Last updated on Jul 26, 2024.
Excipient (pharmacologically inactive substance)
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.[1]
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.[2]
Some examples of medications containing Povidone K25
- Acyclovir 200 mg
- Acyclovir 400 mg
- Acyclovir 800 mg
- Dextromethorphan Hydrobromide and Guaifenesin Extended-Release 30 mg / 600 mg
- EContra EZ levonorgestrel 1.5 mg
- Ethinyl Estradiol and Norethindrone Acetate ethinyl estradiol 20 mcg / norethindrone acetate 1 mg
- Ethinyl Estradiol and Norethindrone Acetate ethinyl estradiol 0.02 mg / norethindrone acetate 1 mg
- Fenofibrate 134 mg
- Mucus DM Maximum Strength dextromethorphan hydrobromide 60 mg / guaifenesin 1200 mg
- Omeprazole Delayed Release 40 mg
- Pantoprazole Sodium Delayed Release 20 mg
- Pantoprazole Sodium Delayed Release 40 mg
- Protonix 40 mg
- Quetiapine Fumarate 100 mg
- Quetiapine Fumarate 25 mg
- Quetiapine Fumarate 50 mg
- Spironolactone 50 mg
- Spironolactone 100 mg
- Spironolactone 25 mg
- Tramadol Hydrochloride 50 mg
References
- Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
- Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.