Povidone
Excipient (pharmacologically inactive substance)
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It also acts as a disintegrant and tablet binder. It appears as white to off-white hygroscopic powder in its pure form and is readily soluble in water. Povidone has the molecular formula of (C6H9NO)n. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents.[1]
Povidone’s most common use is in the topical povidone-iodine solution (Aerodine, Betadine), where iodine is released as an antiseptic. Povidone-iodine is often used to prevent surgical incision infections. Povidone has also been used as blood volume expander and as an antibacterial in dental procedures. Chlorhexidine-alcohol is also used topically as a pre-operative surgical antiseptic and has been shown in one study to have slightly better antimicrobial activity.[2]
[1] [1]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] Rabih, et al. Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. NEJM 2010:362:18-26.
Top Medications with this excipient
- Acetaminophen 500mg (Kroger Company)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg (Mallinckrodt Pharmaceuticals)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg (Mallinckrodt Pharmaceuticals)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg (Mallinckrodt Pharmaceuticals)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg (Watson Pharmaceuticals)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg (Qualitest Pharmaceuticals Inc.)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg (Qualitest Pharmaceuticals Inc.)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg (Sun Pharmaceutical Industries Inc.)
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg (Watson Pharmaceuticals)
- Acetaminophen and Hydrocodone Bitartrate 500 mg / 5 mg (Mallinckrodt Pharmaceuticals)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg (Mallinckrodt Pharmaceuticals)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg (Amneal Pharmaceuticals)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg (Mallinckrodt Pharmaceuticals)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg (Qualitest Pharmaceuticals Inc.)
- Cetirizine Hydrochloride 10 mg (Perrigo Company)
- Loratadine 10 mg (Perrigo Company)
- Methocarbamol 750 mg (Qualitest Pharmaceuticals Inc.)
- Methocarbamol 500 mg (Qualitest Pharmaceuticals Inc.)
- Naproxen 500 mg (Glenmark Generics Inc.)
- Sulfamethoxazole and Trimethoprim DS 800 mg / 160 mg (Amneal Pharmaceuticals)
