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Pretomanid and Alcohol/Food Interactions

There is 1 alcohol/food/lifestyle interaction with pretomanid.

Moderate

pretomanid food

Moderate Food Interaction

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of pretomanid. The mechanism has not been reported. Compared with the fasted state, oral administration of pretomanid with a high-fat, high-calorie meal (approximately 150, 250, and 500 to 600 calories from protein, carbohydrate, and fat, respectively) increased mean systemic exposure (AUC) and peak plasma concentration (Cmax) of pretomanid by 88% and 76%, respectively.

MANAGEMENT: To ensure maximal oral absorption, pretomanid should be administered with food. Tablets should be swallowed whole.

References

  1. "Product Information. Pretomanid (pretomanid)." The Global Alliance for TB Drug Development (2019):

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Pretomanid drug interactions

There are 54 drug interactions with pretomanid.

Pretomanid disease interactions

There are 2 disease interactions with pretomanid which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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