Pretomanid Disease Interactions
There are 2 disease interactions with pretomanid.
Pretomanid (applies to pretomanid) hepatic dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Alcoholism
The effect of liver dysfunction on the safety, effectiveness, and pharmacokinetics of pretomanid has not been established. The combination regimen of pretomanid, bedaquiline, and linezolid has been associated with hepatic adverse reactions; alcohol and hepatotoxic agents should be avoided during pretomanid treatment, especially in patients with liver dysfunction. It is recommended to monitor signs and symptoms of hepatotoxicity and laboratory tests (ALT, AST, alkaline phosphatase, and bilirubin) at least at baseline, at 2 weeks, and then monthly while on treatment and as needed. If evidence of new or worsening liver dysfunction occurs, it is recommended to test for viral hepatitides and discontinue other hepatotoxic medications.
Pretomanid (applies to pretomanid) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
The effect of renal dysfunction on the safety, effectiveness, and pharmacokinetics of pretomanid has not been established.
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Pretomanid drug interactions
There are 254 drug interactions with pretomanid.
Pretomanid alcohol/food interactions
There is 1 alcohol/food interaction with pretomanid.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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