No information is available on the use of pretomanid during breastfeeding, although the estimated dose for a breastfed infant is low. If pretomanid is required by the mother, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Drug Levels
Maternal Levels. Using a computed milk-to-plasma ratio of 0.89, one group of authors estimated that a fully breastfed infant would receive a pretomanid dosage of 1.02 mcg/kg daily with a standard maternal dose of 200 mg daily.[1] However, the authors used a nonstandard milk volume in their calculation. Using the standard 150 mL/kg daily, the estimated infant dosage would be 0.83 mcg/kg daily.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
1.
Algharably EA, Kreutz R, Gundert-Remy U. Infant exposure to antituberculosis drugs via breast milk and assessment of potential adverse effects in breastfed infants: Critical review of data. Pharmaceutics. 2023;15:1228. [PMC free article: PMC10143885] [PubMed: 37111713]
Substance Identification
Substance Name
Pretomanid
CAS Registry Number
187235-37-6
Drug Class
Breast Feeding
Lactation
Milk, Human
Anti-infective Agents
Antitubercular Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
