Ofev and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Ofev (nintedanib).
Nintedanib Food/Lifestyle
Moderate Food Interaction
Grapefruit juice and Seville orange juice can increase the blood levels of nintedanib. This may increase the risk and/or severity of side effects such as liver problems, diarrhea, nausea, vomiting, stomach or intestinal wall perforation, bleeding, and cardiovascular problems such as heart attack, chest pain, or stroke. It is best to avoid or minimize the consumption of Seville oranges, Seville orange juice, grapefruit, and grapefruit juice during treatment. You should take nintedanib with food and swallow it whole with water. Taking nintedanib with food may help with absorption of the medication and reduce gastrointestinal side effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
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Ofev drug interactions
There are 252 drug interactions with Ofev (nintedanib).
Ofev disease interactions
There are 6 disease interactions with Ofev (nintedanib) which include:
- arterial thromboembolism
- bleeding
- gastrointestinal perforation
- hepatic impairment
- renal impairment
- smoking
More about Ofev (nintedanib)
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- FDA approval history
- Drug class: multikinase inhibitors
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.